Article
Perturbing Enhancer Activity in Cancer Therapy
2019-03-30
Abstract excerpt
Tight regulation of gene transcription is essential for normal development, tissue homeostasis and disease-free survival. Enhancers are distal regulatory elements in the genome that provide specificity to gene expression programs and are frequently misregulated in cancer. Recent studies examined various enhancer-driven malignant dependencies and identified different approaches to specifically target these programs...
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Identifiers and source
- Literature Corpus work
- 2a71c183-baf0-594e-8378-5a8380618f7d
- DOI
- 10.20944/preprints201903.0288.v1