Article
Enhancer release and retargeting activates disease-susceptibility genes.
Nature - 1 Jul 2021
Oh Soohwan, Shao Jiaofang, Mitra Joydeep, Xiong Feng, D'Antonio Matteo, Wang Ruoyu, Garcia-Bassets Ivan, Ma Qi, Zhu Xiaoyu, Lee Joo-Hyung, Nair Sreejith J, Yang Feng, Ohgi Kenneth, Frazer Kelly A, Zhang Zhengdong D, Li Wenbo, Rosenfeld Michael G
Abstract excerpt
The functional engagement between an enhancer and its target promoter ensures precise gene transcription1. Understanding the basis of promoter choice by enhancers has important implications for health and disease. Here we report that functional loss of a preferred promoter can release its partner enhancer to loop to and activate an alternative promoter (or alternative promoters) in the neighbourhood. We refer to...
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