Article

<i>In vitro</i> selection of Engineered Transcriptional Repressors for targeted epigenetic silencing and initial evaluation of their specificity profile

2022-08-31

Abstract excerpt

<h4>ABSTRACT</h4> Gene inactivation is instrumental to study gene function and represents a promising strategy for the treatment of a broad range of diseases. Among traditional technologies, RNA interference suffers from partial target abrogation and requirement for life-long treatments. On the other hand, artificial nucleases can impose stable gene inactivation through induction of DNA Double Strand Breaks, but...

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Literature Corpus work: 539506a1-f1a1-596c-9dec-ff4a16fa737d
DOI: 10.1101/2022.08.30.505942

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