Article

Alzheimer’s disease genetic risk and sleep phenotypes: association with more slow-waves and daytime sleepiness

2020-02-27

Abstract excerpt

<h4>Study Objectives</h4> Sleep disturbances and genetic variants have been identified as risk factors for Alzheimer’s disease. Our goal was to assess whether genome-wide polygenic risk scores (PRS) for AD associate with sleep phenotypes in young adults, decades before typical AD symptom onset. <h4>Methods</h4> We computed whole-genome Polygenic Risk Scores (PRS) for AD and extensively phenotyped sleep under diffe...

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Literature Corpus work: 1d5048c9-0899-5387-9871-dbfd7820f1bb
DOI: 10.1101/2020.02.26.20027912

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