Article

Comprehensive investigation of sleep architecture by <i>APOE</i> genotype: <i>APOE4</i> homozygotes have higher arousal thresholds

2025-06-02

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and Objectives</h4> APOE4 , a genetic risk factor for Alzheimer’s Disease (AD), is associated with reduced functional connectivity of brain regions that regulate sleep, which may predispose persons to AD via altering sleep architecture. However, little is known about differences in sleep architecture by APOE genotype. <h4>Methods</h4> This cross-sectional study examined the as...

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Literature Corpus work: 9b958a34-0483-5031-86c4-b8a37a847bca
DOI: 10.1101/2025.05.30.656615

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