Article
Genetic Risk of Alzheimer's Disease and Sleep Duration in Non-Demented Elders.
Annals of neurology - 1 Jan 2021
Leng Yue, Ackley Sarah F, Glymour Maria M, Yaffe Kristine, Brenowitz Willa D
Abstract excerpt
Growing evidence has suggested an association between sleep duration and Alzheimer's disease (AD), but it is unclear if sleep duration is a manifestation of the AD disease process. We studied whether genetic liability for AD predicts sleep duration using a genetic risk score (GRS) for AD (AD-GRS), in 406,536 UK Biobank participants with European ancestry and without dementia at enrollment. Higher AD-GRS score was...
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