Article
Alzheimer's disease genetic risk and sleep phenotypes in healthy young men: association with more slow waves and daytime sleepiness.
Sleep - 21 Jan 2021
Muto Vincenzo, Koshmanova Ekaterina, Ghaemmaghami Pouya, Jaspar Mathieu, Meyer Christelle, Elansary Mahmoud, Van Egroo Maxime, Chylinski Daphne, Berthomier Christian, Brandewinder Marie, Mouraux Charlotte, Schmidt Christina, Hammad Grégory, Coppieters Wouter, Ahariz Naima, Degueldre Christian, Luxen André, Salmon Eric, Phillips Christophe, Archer Simon N, Yengo Loic, Byrne Enda, Collette Fabienne, Georges Michel, Dijk Derk-Jan, Maquet Pierre, Visscher Peter M, Vandewalle Gilles
Abstract excerpt
STUDY OBJECTIVES: Sleep disturbances and genetic variants have been identified as risk factors for Alzheimer's disease (AD). Our goal was to assess whether genome-wide polygenic risk scores (PRS) for AD associate with sleep phenotypes in young adults, decades before typical AD symptom onset. METHODS: We computed whole-genome PRS for AD and extensively phenotyped sleep under different sleep conditions, including...
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