Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sleep complaints and genetic risk of Alzheimer's disease in older women: associations with memory and tau deposition.

The journal of prevention of Alzheimer's disease - 1 Aug 2026

Lui Kitty K, Wang Xin, Dratva Melanie A, Lifset Ella T, Stiver Jordan, Heyworth Nadine C, Shen Qian, Thomas Michael, DeYoung Pamela N, Malhotra Atul, Sundermann Erin E, Banks Sarah J

Abstract excerpt

BACKGROUND: Emerging evidence point to a bidirectional relationship between sleep disturbances and Alzheimer's disease (AD). Poor sleep may be an overlooked risk factor for older women, who are disproportionately affected by AD and report worse subjective sleep quality than men. High genetic AD risk-characterized by the polygenic hazard score (PHS), including apolipoprotein (APOE) ε4 carriership-may further...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein E4
Share to Genetic Risk Score

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Memory

Share to Memory Disorders

Share to Neuropsychological Tests

Share to Positron-Emission Tomography

Share to Sleep Wake Disorders

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 42096939
DOI: 10.1016/j.tjpad.2026.100581
PMCID: PMC13156732

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sleep complaints and genetic risk of Alzheimer's disease in older women: associations with memory and tau deposition.PMID 42096939Read ↗

Subjective sleep traits and cognition across mid- to late-adulthood: a cross-sectional study of gene-environment interplay.Semantic proximity Read ↗

Sex-specific early cognitive changes are linked to global and pathway-specific genetic risk for Alzheimer's disease in at-risk individuals.Semantic proximity Read ↗

Amyloid-β and APOE genotype predict memory decline in cognitively unimpaired older individuals independently of Alzheimer's disease polygenic risk score.Semantic proximity Read ↗

Modification of the relationship of the apolipoprotein E ε4 allele to the risk of Alzheimer disease and neurofibrillary tangle density by sleep.Semantic proximity Read ↗

Age-related polygenic effects of Alzheimer's disease on brain structures and cognition in middle aged and elderly adults from UK BiobankSemantic proximity Read ↗

Genetic Risk for Alzheimer's Disease Moderates the Association Between Medial Temporal Lobe Volume and Episodic Memory Performance Among Older Adults.Semantic proximity Read ↗

Alzheimer’s disease genetic risk and sleep phenotypes: association with more slow-waves and daytime sleepinessSemantic proximity Read ↗

Sex moderates apolipoprotein E ε4 effects on sleep expression and memory retentionSemantic proximity Read ↗

Alzheimer's disease genetic risk and sleep phenotypes in healthy young men: association with more slow waves and daytime sleepiness.Semantic proximity Read ↗

Reduced rapid eye movement sleep in late middle-aged and older apolipoprotein E ɛ4 allele carriers.Semantic proximity Read ↗

Utility of an Alzheimer’s Disease Risk-Weighted Polygenic Risk Score for Predicting Rates of Cognitive Decline in Preclinical Alzheimer’s Disease: A Prospective Longitudinal StudySemantic proximity Read ↗

White Matter Microstructural Alterations Mediate the Association between Polygenic Risk for Alzheimer's Disease and Cognitive Performance in Clinically Asymptomatic Adults.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.