Article

Sleep arousals are associated with the polygenic risk for developing Alzheimer's disease and with cognitive decline in healthy late middle-aged individuals

2025-11-13

Abstract excerpt

<h4>Objective: </h4> Sleep disturbances are increasingly recognized as early features of Alzheimer's disease (AD) neuropathology. In that context, spontaneous arousals during sleep have been associated with the burden of Amyloid beta in the brain of healthy late middle-aged individuals. Whether the heterogeneity of arousals during sleep may be related to the genetic risk of developing AD in young adults is not est...

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Literature Corpus work: ed1af97a-9cda-5c31-b2d6-1ffd1490457d
DOI: 10.1101/2025.11.11.687823

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