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Article

Subjective sleep traits and cognition across mid- to late-adulthood: a cross-sectional study of gene-environment interplay.

Sleep - 14 Aug 2026

Vo-Eckerle Tina T, Gillespie Nathan A, Christensen Kaare, Finkel Deborah, Kremen William S, Nygaard Marianne, Sachdev Perminder S, Thalamuthu Anbupalam, Reynolds Chandra A

Abstract excerpt

Genetic susceptibility to Alzheimer's disease (AD) may influence the extent to which environmental factors shape cognition, with individuals at higher genetic risk potentially exhibiting greater sensitivity to environmental exposures. Sleep, an important factor for both cognitive function and AD risk, may further moderate genetic influences (A), including both measured (AP) and latent (AL) components, as well as...

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Identifiers

PMID: 42059651
DOI: 10.1093/sleep/zsag119
PMCID: PMC13472895

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APOE

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