Article

A Novel PI3K-driven Mouse Model of Intrahepatic Cholangiocarcinoma and Synergistic Antitumor Effects of Combined PI3K and WEE1 Inhibition

2026-06-12

Abstract excerpt

<title>Abstract</title> <p> Cholangiocarcinoma (CCA) is a highly aggressive malignancy with limited therapeutic options. Genomic studies frequently identify alterations in the PI3K pathway and <italic>TP53</italic> ; however, their roles in cholangiocarcinogenesis and therapeutic vulnerabilities remain unclear. We generated two genetically engineered mouse models of intrahepatic CCA by combining <italic>Pik3c...

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Literature Corpus work: 1d380a83-a93a-585c-a855-9a287eb332ed
DOI: 10.21203/rs.3.rs-9508063/v1

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