Article
Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinoma.
Cancer research - 15 Mar 2012
O'Dell Michael R, Huang Jing Li, Whitney-Miller Christa L, Deshpande Vikram, Rothberg Paul, Grose Valerie, Rossi Randall M, Zhu Andrew X, Land Hartmut, Bardeesy Nabeel, Hezel Aram F
Abstract excerpt
Intrahepatic cholangiocarcinoma (IHCC) is a primary cancer of the liver with an increasing incidence and poor prognosis. Preclinical studies of the etiology and treatment of this disease are hampered by the relatively small number of available IHCC cell lines or genetically faithful animal models. Here we report the development of a genetically engineered mouse model of IHCC that incorporates two of the most...
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