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Article

The heterogeneity of signaling pathways and drug responses in intrahepatic cholangiocarcinoma with distinct genetic mutations.

Cell death & disease - 11 Jan 2024

Feng Yangyang, Zhao Ming, Wang Lijian, Li Ling, Lei Josh Haipeng, Zhou Jingbo, Chen Jinghong, Wu Yumeng, Miao Kai, Deng Chu-Xia

Abstract excerpt

Intrahepatic cholangiocarcinoma (ICC) is the second most common malignancy among primary liver cancers, with an increasing overall incidence and poor prognosis. The intertumoral and intratumoral heterogeneity of ICC makes it difficult to find efficient drug therapies. Therefore, it is essential to identify tumor suppressor genes and oncogenes that induce ICC formation and progression. Here, we performed...

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Source

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Identifiers

PMID: 38212325
DOI: 10.1038/s41419-023-06406-7
PMCID: PMC10784283

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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