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Article

Establishment of a patient-derived intrahepatic cholangiocarcinoma xenograft model with KRAS mutation.

BMC cancer - 11 Feb 2016

Cavalloni Giuliana, Peraldo-Neia Caterina, Sassi Francesco, Chiorino Giovanna, Sarotto Ivana, Aglietta Massimo, Leone Francesco

Abstract excerpt

BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is an aggressive, highly lethal tumors and lacks of effective chemo and targeted therapies. Cell lines and animal models, even partially reflecting tumor characteristics, have limits to study ICC biology and drug response. In this work, we created and characterized a novel ICC patient-derived xenograft (PDX) model of Italian origin. METHODS: Seventeen primary ICC...

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Share to Cholangiocarcinoma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Liver Neoplasms

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Share to Proto-Oncogene Proteins p21(ras)

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Source

Open in PubMed Open full text

Identifiers

PMID: 26868125
DOI: 10.1186/s12885-016-2136-1
PMCID: PMC4750214

Genes

EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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