Article

<i>In vivo</i> modelling of patient genetic heterogeneity identifies concurrent Wnt and PI3K activity as a potent driver of invasive cholangiocarcinoma growth

2021-07-05

Abstract excerpt

Intrahepatic cholangiocarcinoma (ICC) is an aggressive and lethal malignancy of the bile ducts within the liver characterised by high levels of genetic heterogeneity. In the context of such genetic variability, determining which oncogenic mutations drive ICC growth has been difficult and developing modes of patient stratification and targeted therapies remains challenging. As a result, survival rates following a d...

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Literature Corpus work: d8109d2e-5728-5249-8032-07a68c3d8758
DOI: 10.1101/2021.07.05.449722

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