Article

FGFR2 fusion protein-driven mouse models of intrahepatic cholangiocarcinoma unveil a necessary role for Erk signaling

2020-05-22

Abstract excerpt

<h4>Background and aims</h4> About 15% of intrahepatic cholangiocarcinoma (iCCA) express fibroblast growth factor receptor 2 (FGFR2) fusion proteins (FFs), most often in concert with mutationally inactivated TP53, CDKN2A or BAP1. FFs span residues 1-768 of FGFR2 fused to sequences encoded by any of a long list (>60) of partner genes, a configuration sufficient to ignite oncogenic FF activation. In line, FGFR-spec...

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Literature Corpus work: 054f144b-67ff-5130-a9ed-21bef0ea4fa2
DOI: 10.1101/2020.05.20.106104

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