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Article

Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.

The Journal of clinical investigation - 1 Jul 2006

Xu Xiaoling, Kobayashi Shogo, Qiao Wenhui, Li Cuiling, Xiao Cuiying, Radaeva Svetlana, Stiles Bangyan, Wang Rui-Hong, Ohara Nobuya, Yoshino Tadashi, LeRoith Derek, Torbenson Michael S, Gores Gregory J, Wu Hong, Gao Bin, Deng Chu-Xia

Abstract excerpt

Cholangiocellular carcinoma (CC), the second most common primary liver cancer, is associated with a poor prognosis. It has been shown that CCs harbor alterations of a number of tumor-suppressor genes and oncogenes, yet key regulators for tumorigenesis remain unknown. Here we have generated a mouse model that develops CC with high penetrance using liver-specific targeted disruption of tumor suppressors SMAD4 and...

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Topics

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Share to Bile Duct Neoplasms
Share to Bile Ducts, Intrahepatic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholangiocarcinoma

Share to Forkhead Box Protein O1

Share to Forkhead Transcription Factors

Share to PTEN Phosphohydrolase

Share to Smad4 Protein

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 16767220
DOI: 10.1172/JCI27282
PMCID: PMC1474816

Genes

PTEN
SMAD4
FOXO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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