Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oncogenic Determination of a Broad Spectrum of Phenotypes of Hepatocyte-Derived Mouse Liver Tumors.

The American journal of pathology - 1 Dec 2017

Yamamoto Masahiro, Xin Bing, Watanabe Kenji, Ooshio Takako, Fujii Kiyonaga, Chen Xi, Okada Yoko, Abe Hiroaki, Taguchi Yoshimitsu, Miyokawa Naoyuki, Furukawa Hiroyuki, Nishikawa Yuji

Abstract excerpt

Activation of the phosphoinositide 3-kinase-AKT, Yes-associated protein (YAP), and MYC pathways is involved in human liver cancers, including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC). However, the nature of the interactions among these pathways has remained poorly understood. Herein, we demonstrate the coordination of these pathways during the formation of mouse liver tumors induced by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to MYC gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatocytes

Share to Liver Neoplasms

Share to Mice, Inbred C57BL

Share to Phenotype

Source

Identifiers

PMID: 28964793
DOI: 10.1016/j.ajpath.2017.07.022

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oncogenic Determination of a Broad Spectrum of Phenotypes of Hepatocyte-Derived Mouse Liver Tumors.PMID 28964793Read ↗

Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice.Semantic proximity Read ↗

Oncogenic driver genes and tumor microenvironment determine the type of liver cancerSemantic proximity Read ↗

Notch2 controls hepatocyte-derived cholangiocarcinoma formation in miceSemantic proximity Read ↗

The Hippo pathway effector TAZ induces intrahepatic cholangiocarcinoma in mice and is ubiquitously activated in the human diseaseSemantic proximity Read ↗

Genomic progression in mouse models for liver tumors.Semantic proximity Read ↗

Kras-driven heterotopic tumor development from hepatobiliary organoidsSemantic proximity Read ↗

SKP2 cooperates with N-Ras or AKT to induce liver tumor development in mice.Semantic proximity Read ↗

Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor CellsSemantic proximity Read ↗

A Novel PI3K-driven Mouse Model of Intrahepatic Cholangiocarcinoma and Synergistic Antitumor Effects of Combined PI3K and WEE1 InhibitionSemantic proximity Read ↗

Cooperation between MYC and β-catenin in liver tumorigenesis requires Yap/TazSemantic proximity Read ↗

Smad4 restricts injury-provoked biliary proliferation and carcinogenesisSemantic proximity Read ↗

Cholangiocarcinomas can originate from hepatocytes in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.