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Article

The Hidden Genomic and Transcriptomic Plasticity of Giant Marker Chromosomes in Cancer.

Genetics - 1 Mar 2018

Macchia Gemma, Severgnini Marco, Purgato Stefania, Tolomeo Doron, Casciaro Hilen, Cifola Ingrid, L'Abbate Alberto, Loverro Anna, Palumbo Orazio, Carella Massimo, Bianchini Laurence, Perini Giovanni, De Bellis Gianluca, Mertens Fredrik, Rocchi Mariano, Storlazzi Clelia Tiziana

Abstract excerpt

Genome amplification in the form of rings or giant rod-shaped marker chromosomes (RGMs) is a common genetic alteration in soft tissue tumors. The mitotic stability of these structures is often rescued by perfectly functioning analphoid neocentromeres, which therefore significantly contribute to cancer progression. Here, we disentangled the genomic architecture of many neocentromeres stabilizing marker chromosomes...

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Identifiers

PMID: 29279323
DOI: 10.1534/genetics.117.300552
PMCID: PMC5844343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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