Article

Neuronal activity promotes repair by microglial reprogramming following demyelination

2025-11-19

Abstract excerpt

Microglia, the resident immune cells of the central nervous system (CNS), play a multifaceted role in neurological disorders. In multiple sclerosis (MS), a chronic demyelinating and neurodegenerative disease, microglia contribute to inflammation and tissue damage, but can also support repair by clearing myelin debris, limiting inflammation and promoting remyelination and neuroprotection. The timely transition from...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 15ad440b-83e0-5150-ab4b-bf72b53f4128
DOI: 10.1101/2025.11.19.689194

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Neuronal activity promotes repair by microglial reprogramming following demyelinationDOI 10.1101/2025.11.19.689194Read

Decoding Microglial Polarization and Metabolic Reprogramming in Neurodegenerative Diseases: Implications for Disease Progression and TherapySemantic proximity Read

Brain macrophages acquire distinct transcriptomes prior to demyelination in multiple sclerosisSemantic proximity Read

The role of microglial activation in disease progression.Semantic proximity Read

Microglia from patients with multiple sclerosis display a cell-autonomous immune activation stateSemantic proximity Read

Microglial states determine lesion dynamics in multiple sclerosisSemantic proximity Read

Can we switch microglia's phenotype to foster neuroprotection? Focus on multiple sclerosis.Semantic proximity Read

Spinal Cord Microglia Exhibit Impaired Repair Responses to Myelin DamageSemantic proximity Read

Single-cell Transcriptomics Analyses Revealed Specialized Microglial Subsets with Oligodendrocyte-like SignaturesSemantic proximity Read

Microglia reprogram metabolic profiles for phenotype and function changes in central nervous system.Semantic proximity Read

Mapping Leukocyte Dynamics during Neuroinflammation Identifies Meningeal Monocyte-Derived Macrophages as Drivers of Progressive DiseaseSemantic proximity Read

Microglia: The Missing Link to Decipher and Therapeutically Control MS Progression?Semantic proximity Read

Stage-Specific Gene Expression Profiles in Multiple Sclerosis Cortical Lesions Identified via Spatial TranscriptomicsSemantic proximity Read