Article

Brain macrophages acquire distinct transcriptomes prior to demyelination in multiple sclerosis

2021-10-28

Abstract excerpt

Multiple sclerosis (MS) is a disease of the central nervous system (CNS) that is characterized by inflammation and focal areas of demyelination, ultimately resulting in axonal degradation and neuronal loss. Several lines of evidence point towards a role for microglia and other brain macrophages in disease initiation and progression, but exactly how lesion formation is triggered is currently unknown. Here, we chara...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fa71445c-0f79-52b1-a86d-01291efb8c2d
DOI: 10.1101/2021.10.27.465877

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Brain macrophages acquire distinct transcriptomes prior to demyelination in multiple sclerosisDOI 10.1101/2021.10.27.465877Read

Stage-Specific Gene Expression Profiles in Multiple Sclerosis Cortical Lesions Identified via Spatial TranscriptomicsSemantic proximity Read

Microglial states determine lesion dynamics in multiple sclerosisSemantic proximity Read

Single-Cell Multi-Omics Map of Cell Type–Specific Mechanistic Drivers of Multiple Sclerosis LesionsSemantic proximity Read

Neuronal activity promotes repair by microglial reprogramming following demyelinationSemantic proximity Read

MS Atlas - A molecular map of brain lesion stages in progressive multiple sclerosisSemantic proximity Read

Single nuclei RNAseq stratifies multiple sclerosis patients into distinct white matter glial responsesSemantic proximity Read

Spatial cell type mapping of multiple sclerosis lesionsSemantic proximity Read

Microglia from patients with multiple sclerosis display a cell-autonomous immune activation stateSemantic proximity Read

Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brainSemantic proximity Read

Human disease-specific cell signatures in non-lesional tissue in Multiple Sclerosis detected by single-cell and spatial transcriptomicsSemantic proximity Read

Mapping Leukocyte Dynamics during Neuroinflammation Identifies Meningeal Monocyte-Derived Macrophages as Drivers of Progressive DiseaseSemantic proximity Read

Patient-derived lymphocytes drive smoldering lesion pathology in a chimeric multiple sclerosis mouse modelSemantic proximity Read