Article

Pubertal development and hypothalamic-pituitary-gonadal axis are altered in male mice lacking <i>Mecp2</i>

2025-08-20

Abstract excerpt

<h4>Background</h4> Mutations in the MECP2 gene, encoding the epigenetic reader Methyl-CpG binding protein 2, are the main cause of Rett syndrome, a rare neurodevelopmental disorder. Besides severe symptoms such as profound intellectual disability, loss of speech and motor skills and epilepsy, loss of function of MECP2 has been associated with pubertal dysregulation, but the biological mechanisms leading to thi...

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Literature Corpus work: 677d52dd-d019-5c0b-b688-c2a4b6d1d4cd
DOI: 10.1101/2025.08.19.671012

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