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Article

Early motor phenotype detection in a female mouse model of Rett syndrome is improved by cross-fostering.

Human molecular genetics - 15 May 2017

Vogel Ciernia Annie, Pride Michael C, Durbin-Johnson Blythe, Noronha Adriana, Chang Alene, Yasui Dag H, Crawley Jacqueline N, LaSalle Janine M

Abstract excerpt

Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in the gene encoding methyl CpG binding protein 2 (MeCP2) that occur sporadically in 1:10,000 female births. RTT is characterized by a period of largely normal development followed by regression in language and motor skills at 6-18 months of age. Mecp2 mutant mice recapitulate many of the clinical features of RTT, but the majority...

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Identifiers

PMID: 28334953
DOI: 10.1093/hmg/ddx087
PMCID: PMC6075042

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