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Article

Integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D-associated genes and regulatory signals.

Cell reports - 26 Aug 2025

D'Oliveira Albanus Ricardo, Zhang Xiaoshan, Zhao Zeping, Taylor Henry J, Tang Xuming, Han Yuling, Orchard Peter, Varshney Arushi, Zhang Tuo, Manickam Nandini, Erdos Michael R, Narisu Narisu, Taylor Leland, Saavedra Xiaxia, Liu Xinyi, Zhong Aaron, Li Bo, Zhou Ting, Naji Ali, Liu Chengyang, Collins Francis S, Parker Stephen C J, Chen Shuibing

Abstract excerpt

Genome-wide association studies (GWASs) have identified over 100 signals associated with type 1 diabetes (T1D). However, it has been challenging to translate any given T1D GWAS signal into mechanistic insights, such as causal variants, their target genes, and the specific cell types involved. Here, we present a comprehensive multi-omic integrative analysis of single-cell/nucleus resolution profiles of gene...

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Identifiers

PMID: 40737125
DOI: 10.1016/j.celrep.2025.116065
PMCID: PMC12477748

Genes

DLK1
RASGRP1
TOX

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Integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D-associated genes and regulatory signals.PMID 40737125Read ↗

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