Article

Integrated meta-analysis of public human pancreatic single-cell transcriptomes reveals distinct beta-cell state trajectories across aging and diabetes

2026-01-29

Abstract excerpt

<h4>SUMMARY</h4> Human pancreas single-cell RNA sequencing (scRNA-seq) studies have revealed extensive islet heterogeneity, yet cross-study integration remains limited by cohort- and platform-specific effects. Here, we assembled a unified atlas of >266,000 human pancreatic cells by harmonizing 18 publicly available scRNA-seq datasets spanning diverse technologies and donor phenotypes. Trajectory-based analyses re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0fd1fd62-5dbc-518f-9c14-60f79e336389
DOI: 10.64898/2026.01.27.701674

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated meta-analysis of public human pancreatic single-cell transcriptomes reveals distinct beta-cell state trajectories across aging and diabetesDOI 10.64898/2026.01.27.701674Read

The Human Pancreas Cell Atlas defines a healthy reference framework for disease contextualization and translational benchmarkingSemantic proximity Read

PanKbase Integrated Single-Cell Map: A Comprehensive Atlas of Human Pancreatic IsletsSemantic proximity Read

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories toward type 2 diabetesSemantic proximity Read

Aging of human endocrine pancreatic cell types is heterogeneous and sex-specificSemantic proximity Read

Identification of unique cell type responses in pancreatic islets to stressSemantic proximity Read

A transcriptional cross species map of pancreatic islet cellsSemantic proximity Read

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetesSemantic proximity Read

Single cell multiome profiling of pancreatic islets reveals physiological changes in cell type-specific regulation associated with diabetes riskSemantic proximity Read

Single-cell multiome analysis supports α-to-β transdifferentiation in human pancreasSemantic proximity Read

Endocrine Pancreas Development and Dysfunction Through the Lens of Single-Cell RNA-SequencingSemantic proximity Read

Human Pancreatic α-Cell Heterogeneity and Trajectory Inference Analysis Using Integrated Single Cell- and Single Nucleus-RNA Sequencing PlatformsSemantic proximity Read

Single-cell transcriptome profiling reveals β cell maturation in stem cell-derived islets after transplantationSemantic proximity Read