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Nardilysin regulates <i>Slc2a2</i> expression through ISLET1 recruitment to an evolutionarily conserved enhancer in pancreatic β-cells

2026-02-19

Abstract excerpt

GLUT2 ( Slc2a2 ) is a key glucose transporter in pancreatic β-cells, and its reduced expression is closely linked to defective glucose-stimulated insulin secretion (GSIS) and diabetes. We previously reported that pancreatic β-cell–specific nardilysin (NRDC)-deficient mice (BetaKO) exhibit severe diabetic phenotype with defective GSIS and reduced Slc2a2 expression in islets. However, because BetaKO mice also show...

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Literature Corpus work
1cb06aa7-f289-5dbc-a82c-47c5f143638e
DOI
10.64898/2026.02.19.706474
Open publication

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Nardilysin regulates <i>Slc2a2</i> expression through ISLET1 recruitment to an evolutionarily conserved enhancer in pancreatic β-cellsDOI 10.64898/2026.02.19.706474
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