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Article

LIM domain–binding 1 maintains the terminally differentiated state of pancreatic β cells

11 Dec 2016

Abstract excerpt

The recognition of β cell dedifferentiation in type 2 diabetes raises the translational relevance of mechanisms that direct and maintain β cell identity. LIM domain-binding protein 1 (LDB1) nucleates multimeric transcriptional complexes and establishes promoter-enhancer looping, thereby directing fate assignment and maturation of progenitor populations. Many terminally differentiated endocrine cell types,...

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PMID: 27941246
DOI: 10.1172/jci88016

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