Single-cell RNA-seq transcriptomic landscape of human and mouse islets and pathological alterations of diabetes

Abstract excerpt

Single-cell RNA sequencing has paved the way for delineating the pancreatic islet cell atlas and identifying hallmarks of diabetes. However, pathological alterations of type 2 diabetes (T2D) remain unclear. We isolated pancreatic islets from control and T2D mice for single-cell RNA sequencing (scRNA-seq) and retrieved multiple datasets from the open databases. The complete islet cell landscape and robust marker...

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• Diabetes and associated disorders
• Pancreatic function and diabetes
• Single-cell and spatial transcriptomics