Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Foxa2 regulates multiple pathways of insulin secretion

16 Aug 2004

Abstract excerpt

The regulation of insulin secretion by pancreatic beta cells is perturbed in several diseases, including adult-onset (type 2) diabetes and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). The first mouse model for PHHI has a conditional deletion of the gene encoding the winged-helix transcription factor Foxa2 (Forkhead box a2, formerly Hepatocyte nuclear factor 3beta) in pancreatic beta cells. Using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Management and Research
Share to Metabolism, Diabetes, and Cancer
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15314688
DOI: 10.1172/jci21149

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Foxa2 regulates multiple pathways of insulin secretionPMID 15314688Read ↗

Novel FOXA2 mutation causes Hyperinsulinism, Hypopituitarism with Craniofacial and Endoderm-derived organ abnormalities.Semantic proximity Read ↗

MicroRNA-124a Regulates Foxa2 Expression and Intracellular Signaling in Pancreatic β-Cell LinesSemantic proximity Read ↗

Congenital Hyperinsulinism and Hypopituitarism Attributable to a Mutation in FOXA2.Semantic proximity Read ↗

Identifying miRNA Signatures Associated with Pancreatic Islet Dysfunction in a FOXA2-Deficient iPSC ModelSemantic proximity Read ↗

Glucose-mediated insulin secretion is improved in FHL2-deficient mice and elevated FHL2 expression in humans is associated with type 2 diabetesSemantic proximity Read ↗

Nardilysin regulates <i>Slc2a2</i> expression through ISLET1 recruitment to an evolutionarily conserved enhancer in pancreatic β-cellsSemantic proximity Read ↗

Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion.Semantic proximity Read ↗

Aberrant development of pancreatic beta cells derived from human iPSCs with FOXA2 deficiencySemantic proximity Read ↗

Genome-wide differential expression profiling of long non-coding RNAs in FOXA2 knockout iPSC-derived pancreatic cellsSemantic proximity Read ↗

Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell.Semantic proximity Read ↗

The Role of ARX in Human Pancreatic Endocrine SpecificationSemantic proximity Read ↗

SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.