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FXYD2 marks and regulates maturity of β cells via ion channel-mediated signal transduction

4 Jun 2025

Abstract excerpt

Human pancreatic islets regulate organ development and metabolic homeostasis, with dysfunction leading to diabetes. Human pluripotent stem cells (hPSCs) provide a potential alternative source to cadaveric human pancreatic islets for replacement therapy in diabetes. However, human islet-like organoids (HILOs) generated from hPSCs in vitro often exhibit heterogeneous immature phenotypes such as aberrant gene...

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PMID: 40467586
DOI: 10.1038/s41467-025-60188-4

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