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Glucocorticoids reduce Slc2a2 ( GLUT2 ) gene expression through HNF1 in pancreatic β-cells

17 Dec 2024

Abstract excerpt

Glucose transporter type 2 (GLUT2), encoded by the Slc2a2 gene, is essential for glucose-stimulated insulin secretion (GSIS) in pancreatic islet β-cells, and low expression of GLUT2 is associated with β-cell dysfunction during the progression of type 2 diabetes in humans and animal models. Glucocorticoids are stress hormones that regulate inflammation and metabolism through the glucocorticoid receptor (GR), a...

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PMID: 39688285
DOI: 10.1530/jme-24-0077

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