Article

Chromatin accessibility profiling uncovers genetic- and T2D disease state-associated changes in <i>cis</i> -regulatory element use in human islets

2017-09-22

Abstract excerpt

Genetic and environmental factors both contribute to islet dysfunction and failure, resulting in type 2 diabetes (T2D). The islet epigenome integrates these cues and can be remodeled by genetic and environmental variation. However, our knowledge of how genetic variants and T2D disease state alter human islet chromatin landscape and cis- regulatory element (RE) use is lacking. To fill this gap, we profiled and ana...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5b41482b-111b-58a1-85b0-5a4fbacca361
DOI: 10.1101/192922

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Chromatin accessibility profiling uncovers genetic- and T2D disease state-associated changes in <i>cis</i> -regulatory element use in human isletsDOI 10.1101/192922Read

Type 2 Diabetes-Associated Genetic Variants Regulate Chromatin Accessibility in Human Islets.Semantic proximity Read

Genetic regulatory signatures underlying islet gene expression and type 2 diabetes.Semantic proximity Read

ATAC-seq reveals alterations in open chromatin in pancreatic islets from subjects with type 2 diabetesSemantic proximity Read

Pancreatic islet chromatin accessibility and conformation defines distal enhancer networks of type 2 diabetes riskSemantic proximity Read

Functional characterization of thousands of type 2 diabetes-associated and chromatin-modulating variants under steady state and endoplasmic reticulum stressSemantic proximity Read

Islet-specific DNA hypomethylation identifies gene enhancer loci driving Type 2 Diabetes riskSemantic proximity Read

A map of open chromatin in human pancreatic islets.Semantic proximity Read

Allele-specific transcriptional activity at type 2 diabetes-associated single nucleotide polymorphisms in regions of pancreatic islet open chromatin at the JAZF1 locus.Semantic proximity Read

Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D.Semantic proximity Read

Single cell chromatin accessibility reveals pancreatic islet cell type- and state-specific regulatory programs of diabetes riskSemantic proximity Read

A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression.Semantic proximity Read

Genetic and epigenetic regulation of gene expression in pancreatic isletsSemantic proximity Read