Article
Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes.
Nature communications - 6 Jun 2017
Axelsson A S, Mahdi T, Nenonen H A, Singh T, Hänzelmann S, Wendt A, Bagge A, Reinbothe T M, Millstein J, Yang X, Zhang B, Gusmao E G, Shu L, Szabat M, Tang Y, Wang J, Salö S, Eliasson L, Artner I, Fex M, Johnson J D, Wollheim C B, Derry J M J, Mecham B, Spégel P, Mulder H, Costa I G, Zhang E, Rosengren A H
Abstract excerpt
Type 2 diabetes (T2D) is characterized by insulin resistance and impaired insulin secretion, but the mechanisms underlying insulin secretion failure are not completely understood. Here, we show that a set of co-expressed genes, which is enriched for genes with islet-selective open chromatin, is associated with T2D. These genes are perturbed in T2D and have a similar expression pattern to that of dedifferentiated...
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