ARID1A loss in pancreas leads to islet developmental defect and metabolic disturbance

Abstract excerpt

ARID1A is a tumor suppressor gene mutated in 7–10% of pancreatic cancer patients. However, its function in pancreas development and endocrine regulation is unclear. We generated mice that lack Arid1a expression in the pancreas. Our results showed that deletion of the Arid1a gene in mice caused a reduction in islet numbers and insulin production, both of which are associated with diabetes mellitus (DM) phenotype....

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