Article

Parallel gene expression changes in ventral midbrain dopamine and GABA neurons during normal aging

2025-03-03

Abstract excerpt

The consequences of aging can vary dramatically between different brain regions and cell types. In the ventral midbrain, dopaminergic neurons develop physiological deficits with normal aging that likely convey susceptibility to neurodegeneration. While nearby GABAergic neurons are thought to be more resilient, decreased GABA signaling in other areas nonetheless correlates with age-related cognitive decline and the...

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Literature Corpus work: 1c53d5f0-4edb-5e27-8fec-bb3392d1b6b2
DOI: 10.1101/2025.02.28.640868

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