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Article

ADNP is essential for sex-dependent hippocampal neurogenesis, through male unfolded protein response and female mitochondrial gene regulation.

Molecular psychiatry - 1 Jun 2025

Shapira Guy, Karmon Gidon, Hacohen-Kleiman Gal, Ganaiem Maram, Shazman Shula, Theotokis Paschalis, Grigoriadis Nikolaos, Shomron Noam, Gozes Illana

Abstract excerpt

Essential for brain formation and protective against tauopathy, activity-dependent neuroprotective protein (ADNP) is critical for neurogenesis and cognitive functions, while regulating steroid hormone biogenesis. As such, de novo mutations in ADNP lead to syndromic autism and somatic ADNP mutations parallel Alzheimer's disease progression. Furthermore, clinical trials with the ADNP fragment NAP (the...

Read the complete abstract on PubMed

Topics

Animals
Female
Male
Neurogenesis
Mice
Hippocampus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Unfolded Protein Response

Mitochondria

Nerve Tissue Proteins

Humans

Mutation

Sex Characteristics

Alzheimer Disease

Mice, Inbred C57BL

Sex Factors

Neurons

Homeodomain Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 39715923
DOI: 10.1038/s41380-024-02879-w
PMCID: PMC12092271

Genes

ADNP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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