Back to search

Article

Aging disrupts the coordination between mRNA and protein expression in mouse and human midbrain

2024-06-01

Abstract excerpt

Age-related dopamine (DA) neuron loss is a primary feature of Parkinson’s disease. However, it remains unclear whether similar biological processes occur during healthy aging, albeit to a lesser degree. We therefore determined whether midbrain DA neurons degenerate during aging in mice and humans. In mice, we identified no changes in midbrain neuron numbers throughout aging. Despite this, we found age-related decr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3c117ebd-ab33-5868-8beb-7febcce6c0d9
DOI
10.1101/2024.06.01.596950
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Aging disrupts the coordination between mRNA and protein expression in mouse and human midbrainDOI 10.1101/2024.06.01.596950
Parallel gene expression changes in ventral midbrain dopamine and GABA neurons during normal agingSemantic proximity
Transcriptomic atlas of midbrain dopamine neurons uncovers differential vulnerability in a Parkinsonism lesion modelSemantic proximity
Age-related gene expression changes in substantia nigra dopamine neurons of the rat.Semantic proximity
Striatal pathology in Spinocerebellar Ataxia Type 1 mice: A comparative study with Huntington’s diseaseSemantic proximity
Molecular Regulation in Dopaminergic Neuron Development. Cues to Unveil Molecular Pathogenesis and Pharmacological Targets of Neurodegeneration.Semantic proximity
Pathological characteristics of axons and proteome patterns in midbrain dopaminergic neurodegeneration induced by WDR45-deficiencySemantic proximity
Modelling human neuronal catecholaminergic pigmentation in rodents recapitulates age-related multisystem neurodegenerative deficitsSemantic proximity
Transcriptome responses to reduced dopamine in the Substantia Nigra Pars Compacta reveals a potential protective role for dopamineSemantic proximity
In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons.Semantic proximity
Age-dependent brain pigmentation drives early neuroinflammatory molecular signatures linked to neurodegenerationSemantic proximity
Expression analysis of dopaminergic neurons in Parkinson’s disease and aging links transcriptional dysregulation of energy metabolism to cell deathSemantic proximity
Sex-Dependent Effects of Glutamatergic Disruption on Dopaminergic Neuron Subtype Vulnerable in Parkinson’s DiseaseSemantic proximity
Select a neighboring publication to make it the new centre.