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Auxin-inducible degradation of UNC-116 in <i>C. elegans</i> inhibits bidirectional dense core vesicle transport and worm locomotion on different timescales

2025-06-24

Abstract excerpt

The microtubule motor kinesin-1 is vital in neurons, with mutations being associated with neurological diseases. Deletion of the Caenorhabditis elegans kinesin-1 gene unc-116 is lethal, and viable mutants are uncoordinated. Here, we use auxin-mediated degradation to deplete UNC-116 protein at different developmental stages and monitor the effects on cargo transport and locomotion. UNC-116 is substantially degrad...

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Identifiers and source

Literature Corpus work
1c35deae-88eb-503f-9bea-f36df453ae73
DOI
10.1101/2025.06.23.661018
Open publication

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Auxin-inducible degradation of UNC-116 in <i>C. elegans</i> inhibits bidirectional dense core vesicle transport and worm locomotion on different timescalesDOI 10.1101/2025.06.23.661018
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