Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans.

doi:10.1016/0092-8674(91)90391-b

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Article

Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans.

Cell - 31 May 1991

Hall D H, Hedgecock E M

Abstract excerpt

unc-104 encodes a novel kinesin paralog that may act as a microtubule-based motor in the nervous system. Neuronal cell lineages and axonogenesis are normal in unc-104 null mutants, but axons have few synaptic vesicles and make only a few small synapses. By contrast, neuron cell bodies have surfeits of similar vesicles tethered together within the cytoplasm. Based on behavioral and cellular phenotypes, we suggest...

Topics

Adenosine Triphosphatases
Animals
Axonal Transport
Axons
Caenorhabditis
Cytoplasmic Granules
Embryo, Nonmammalian
Fertility
Genes
Kinesins
Larva
Microscopy, Electron

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microtubule Proteins

Movement

Muscle Contraction

Mutation

Neuromuscular Junction

Synaptic Vesicles

Source

Open in PubMed

Identifiers

PMID: 1710172
DOI: 10.1016/0092-8674(91)90391-b

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1710172-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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