Article
Synapse-Assembly Proteins Maintain Synaptic Vesicle Cluster Stability and Regulate Synaptic Vesicle Transport in Caenorhabditis elegans.
Genetics - 1 Sept 2015
Edwards Stacey L, Yorks Rosalina M, Morrison Logan M, Hoover Christopher M, Miller Kenneth G
Abstract excerpt
The functional integrity of neurons requires the bidirectional active transport of synaptic vesicles (SVs) in axons. The kinesin motor KIF1A transports SVs from somas to stable SV clusters at synapses, while dynein moves them in the opposite direction. However, it is unclear how SV transport is regulated and how SVs at clusters interact with motor proteins. We addressed these questions by isolating a rare...
Topics
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Dendrites
- Dyneins
- Intercellular Signaling Peptides and Proteins
- Intracellular Signaling Peptides and Proteins
- Mutation
- Nerve Tissue Proteins
- Phosphoproteins
- Protein Serine-Threonine Kinases
- Synapses