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Article

Conditional Degradation of UNC-31/CAPS Enables Spatiotemporal Analysis of Neuropeptide Function.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 16 Nov 2022

Cornell Rebecca, Cao Wei, Liu Jie, Pocock Roger

Abstract excerpt

Neuropeptide release from dense-core vesicles in Caenorhabditis elegans is promoted by UNC-31, ortholog of the calcium-dependent activator protein for secretion (CAPS). Loss of UNC-31 causes multiple phenotypes in C. elegans including reduced motility, retention of late-stage eggs, and reduction in evoked synaptic release. However, the ability to analyze UNC-31 function over discrete timescales and in specific...

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Identifiers

PMID: 36302635
DOI: 10.1523/JNEUROSCI.1368-22.2022
PMCID: PMC9671576

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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