Article
CRMP/UNC-33 organizes microtubule bundles for KIF5-mediated mitochondrial distribution to axon.
PLoS genetics - 1 Feb 2021
Chen Ying-Chun, Huang Hao-Ru, Hsu Chia-Hao, Ou Chan-Yen
Abstract excerpt
Neurons are highly specialized cells with polarized cellular processes and subcellular domains. As vital organelles for neuronal functions, mitochondria are distributed by microtubule-based transport systems. Although the essential components of mitochondrial transport including motors and cargo adaptors are identified, it is less clear how mitochondrial distribution among somato-dendritic and axonal compartment...
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