Article

The mIAA7 degron improves auxin-mediated degradation in <i>C. elegans</i>

2022-05-31

Abstract excerpt

Auxin-inducible degradation (AID) is a powerful tool for the targeted degradation of proteins with spatiotemporal control. One limitation of the AID system is that not all proteins are degraded efficiently. Here, we demonstrate that an alternative degron sequence, termed mIAA7, improves the efficiency of degradation in C. elegans , as previously reported in human cells. We tested depletion of a series of proteins...

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Literature Corpus work: 54e24fa1-64b9-5d7b-ac84-703e1282c3c6
DOI: 10.1101/2022.05.31.494192

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