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Article

The role of kinesin-1 in neuronal dense core vesicle transport, locomotion and lifespan regulation in C. elegans.

Journal of cell science - 1 Sept 2024

Gavrilova Anna, Boström Astrid, Korabel Nickolay, Fedotov Sergei, Poulin Gino B, Allan Victoria J

Abstract excerpt

Fast axonal transport is crucial for neuronal function and is driven by kinesins and cytoplasmic dynein. Here, we investigated the role of kinesin-1 in dense core vesicle (DCV) transport in C. elegans, using mutants in the kinesin light chains (klc-1 and klc-2) and the motor subunit (unc-116) expressing an ida-1::gfp transgene that labels DCVs. DCV transport in both directions was greatly impaired in an unc-116...

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Identifiers

PMID: 39171448
DOI: 10.1242/jcs.262148
PMCID: PMC11423817

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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