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Article

Dense core vesicle dynamics in Caenorhabditis elegans neurons and the role of kinesin UNC-104.

Traffic (Copenhagen, Denmark) - 1 Jul 2004

Zahn Tobias R, Angleson Joseph K, MacMorris Margaret A, Domke Erin, Hutton John F, Schwartz Cindi, Hutton John C

Abstract excerpt

We have developed a model system in Caenorhabditis elegans to perform genetic and molecular analysis of peptidergic neurotransmission using green fluorescent protein (GFP)-tagged IDA-1. IDA-1 represents the nematode ortholog of the transmembrane proteins ICA512 and phogrin that are localized to dense core secretory vesicles (DCVs) of mammalian neuroendocrine tissues. IDA-1::GFP was expressed in a small subset of...

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PMID: 15180830
DOI: 10.1111/j.1600-0854.2004.00195.x

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Dense core vesicle dynamics in Caenorhabditis elegans neurons and the role of kinesin UNC-104.PMID 15180830Read ↗

The role of kinesin-1 in neuronal dense core vesicle transport, locomotion and lifespan regulation in C. elegans.Semantic proximity Read ↗

HID-1, a new component of the peptidergic signaling pathway.Semantic proximity Read ↗

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Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans.Semantic proximity Read ↗

Cyclin-dependent kinase 5 regulates the polarized trafficking of neuropeptide-containing dense-core vesicles in Caenorhabditis elegans motor neurons.Semantic proximity Read ↗

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UNC-108/RAB-2 and its effector RIC-19 are involved in dense core vesicle maturation in Caenorhabditis elegans.Semantic proximity Read ↗

Direct visualization of the movement of the monomeric axonal transport motor UNC-104 along neuronal processes in living Caenorhabditis elegans.Semantic proximity Read ↗

Loss of the transcriptional repressor PAG-3/Gfi-1 results in enhanced neurosecretion that is dependent on the dense-core vesicle membrane protein IDA-1/IA-2.Semantic proximity Read ↗

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The EARP Complex and its Interactor EIPR-1 are Required for Cargo Sorting to Dense-Core VesiclesSemantic proximity Read ↗

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