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Article

Genetic regulation of cell type-specific chromatin accessibility shapes brain disease etiology.

Science (New York, N.Y.) - 24 May 2024

Zeng Biao, Bendl Jaroslav, Deng Chengyu, Lee Donghoon, Misir Ruth, Reach Sarah M, Kleopoulos Steven P, Auluck Pavan, Marenco Stefano, Lewis David A, Haroutunian Vahram, Ahituv Nadav, Fullard John F, Hoffman Gabriel E, Roussos Panos

Abstract excerpt

Nucleotide variants in cell type-specific gene regulatory elements in the human brain are risk factors for human disease. We measured chromatin accessibility in 1932 aliquots of sorted neurons and non-neurons from 616 human postmortem brains and identified 34,539 open chromatin regions with chromatin accessibility quantitative trait loci (caQTLs). Only 10.4% of caQTLs are shared between neurons and non-neurons,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38781378
DOI: 10.1126/science.adh4265

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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