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Cell-type specific cis-eQTLs in eight brain cell-types identifies novel risk genes for human brain disorders

2021-10-14

Abstract excerpt

Most expression quantitative trait loci (eQTL) studies to date have been performed in heterogeneous brain tissues as opposed to specific cell types. To investigate the genetics of gene expression in adult human cell types from the central nervous system (CNS), we performed an eQTL analysis using single nuclei RNA-seq from 196 individuals in eight CNS cell types. We identified 6108 eGenes, a substantial fraction (4...

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Literature Corpus work
d9fede33-bf47-5601-ab9e-ac133a638446
DOI
10.1101/2021.10.09.21264604
Open publication

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Cell-type specific cis-eQTLs in eight brain cell-types identifies novel risk genes for human brain disordersDOI 10.1101/2021.10.09.21264604
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