Article

SET1B facilitates activation of the hypoxia response through site-specific histone methylation

2020-12-09

Abstract excerpt

<title>Abstract</title> <p>Hypoxia-inducible transcription factors (HIFs) are fundamental to the cellular adaptation to low oxygen levels but how they interact with chromatin and efficiently activate their target genes is unclear. Using genome-wide mutagenesis in human cancer cells, we define genes required for HIF transcriptional activation, and identify a requirement for the Histone 3 lysine 4 (H3K4) methyltran...

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Literature Corpus work: 1c1fe959-cb7c-5e6e-9cdd-a078ef379d6a
DOI: 10.21203/rs.3.rs-85295/v1

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