Article

WSB-1 regulates DNA repair and the response to DNA damage response inhibitors in breast cancer

2025-09-01

Abstract excerpt

Tumour hypoxia is a poor prognostic factor and linked with metastatic spread and treatment resistance in most solid tumours, including breast cancer. We previously showed hypoxia-regulated E3 ligase WSB-1s association with poor prognosis in breast cancer. Here, we evaluated the role of WSB-1 in DNA repair regulation in breast cancer, and whether these phenotypes can be exploited therapeutically. WSB-1 knockdown le...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4cd1286a-a5e0-5719-a5f2-2908350bf491
DOI: 10.1101/2025.08.27.672589

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

WSB-1 regulates DNA repair and the response to DNA damage response inhibitors in breast cancerDOI 10.1101/2025.08.27.672589Read

hMOB2 deficiency impairs homologous recombination-mediated DNA repair and sensitises cancer cells to PARP inhibitorsSemantic proximity Read

WSB1 promotes tumor metastasis by inducing pVHL degradation.Semantic proximity Read

RBCK1 regulates the progression of ER-positive breast cancer through the HIF1α signalingSemantic proximity Read

Multi-scale characterisation of homologous recombination deficiency in breast cancerSemantic proximity Read

Epigenetic activation of HORMAD1 in basal-like breast cancer: role in Rucaparib sensitivitySemantic proximity Read

Actionable co-alterations in breast tumors with pathogenic mutations in the homologous recombination DNA damage repair pathway.Semantic proximity Read

BRCA1-Dependent and Independent Recruitment of PALB2–BRCA2–RAD51 in the DNA Damage Response and CancerSemantic proximity Read

Jab1 regulates HRR mRNA stability to modulate PARP inhibitor sensitivity in triple-negative breast cancerSemantic proximity Read

Elevated EXO1 expression is associated with breast carcinogenesis and poor prognosisSemantic proximity Read

SET1B facilitates activation of the hypoxia response through site-specific histone methylationSemantic proximity Read

Hypoxanthine Phosphoribosyl Transferase 1 Is Upregulated, Predicts Clinical Outcome and Controls Gene Expression in Breast CancerSemantic proximity Read

ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP InhibitorsSemantic proximity Read