Article

DNA Methylation Repels Binding of HIF Transcription Factors to Maintain Tumour Immunotolerance

2020-02-07

Abstract excerpt

<h4> A bstract </h4> <h4>Background</h4> Hypoxia is pervasive in cancer and other diseases. Cells sense and adapt to hypoxia by activating hypoxia-inducible transcription factors (HIFs), but it is still an outstanding question why cell types differ in their transcriptional response to hypoxia. <h4>Results</h4> Here, we report that HIFs fail to bind CpG dinucleotides that are methylated in their consensus bind...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c014cccb-9688-52ef-a5fa-7d7aa7a5af61
DOI: 10.1101/2020.02.07.931071

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DNA Methylation Repels Binding of HIF Transcription Factors to Maintain Tumour ImmunotoleranceDOI 10.1101/2020.02.07.931071Read

SET1B facilitates activation of the hypoxia response through site-specific histone methylationSemantic proximity Read

Cell-free, methylated DNA in blood samples reveals tissue-specific, cellular damage from radiation treatmentSemantic proximity Read

Epigenetic coordination of transcriptional and translational programs in hypoxiaSemantic proximity Read

5-hydroxymethylcytosines regulate gene expression as a passive DNA demethylation resisting epigenetic mark in proliferative somatic cellsSemantic proximity Read

Immune checkpoint inhibitor response in sarcomas associates with immune infiltrates and increased expression of transposable elements and viral response pathwaysSemantic proximity Read

5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patientsSemantic proximity Read

H3K27me3 is a determinant of chemotolerance in triple-negative breast cancerSemantic proximity Read

Histone methyl-transferase G9a inhibition boosts the efficacy of immune checkpoint inhibitors in experimental hepatocellular carcinomaSemantic proximity Read

Locus-specific enrichment analysis of 5-hydroxymethylcytosine reveals novel genes associated with breast carcinogenesisSemantic proximity Read

Circulating cell-free methylated DNA reveals tissue-specific, cellular damage from radiation treatmentSemantic proximity Read

Enhanced tumor response to adoptive T cell therapy with PHD2/3-deficient CD8 T cellsSemantic proximity Read

Modified Hypoxia Inducible Factor expression in CD8+ T cells increases anti-tumor efficacySemantic proximity Read